Prompt

Nucleosome Remodeling: DNA wrapped around histones (nucleosomes). SWI/SNF complex remodeling chromatin; HATs adding acetyl groups. Mutation labels: "SWI/SNF loss → condensed chromatin". Pre-Initiation Complex: TATA box with TFIID (TBP), TFIIH, RNAPII, and Mediator complex. Phosphorylation of RNAPII CTD. Aberrancy: "TBP mutation → no promoter binding". Initiation/Unwinding: TFIIH helicase (XPB/XPD) unwinding DNA helix. ATP molecules shown. Mutation: "XPB defect → impaired unwinding". Promoter Clearance: RNAPII moving away from promoter; aborted RNA transcripts. Label: "CTD phosphorylation required for clearance". Elongation: RNAPII with nascent RNA (5’→3’); template strand (3’→5’). Uracil in RNA pairing with Adenine in DNA. Aberrancy: "TFIIS rescues stalled RNAPII". Termination: CPSF cleaving RNA at AAUAAA; poly-A polymerase adding adenine tail. Mutation: "AAUAAA mutation → no cleavage". Labels: Color-code DNA (blue), histones (gray), TFs (green), RNAPII (red), RNA (orange), poly-A tail (yellow). Annotate aberrancies in red boxes.

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